Topical Application of Ursolic Acid Cream Ameliorates Imiquimod-induced Plaque Psoriasis in BALB/c Mice

The valued studies of alternative psoriasis treatment options are in a much higher need among the Scientific Community. This study aimed to evaluate anti-psoriatic activity ursolic acid cream imiquimod-induced BALB/c mice. creams containing acid, pentacyclic triterpenoid at percentages 0.1 and 0.2% were formulated. pH, spreadability, physical characteristics acute dermal irritation assessed. Animals grouped into five each having 6 animals. Clobetasol, topical corticosteroid, was used as standard. One group control four groups treated with formulated imiquimod while receiving treatment. Parameters such skin inflammation severity, ear thickness, plasma level interleukins (IL)-17, histology back spleen weight evaluated. Erythema scales scored on daily basis significantly ameliorating psoriatic-like symptoms manner comparable clobetasol. Imiquimod-induced epidermal hyperplasia inhibited by application shown results histopathology. Spleens positive larger comparison rest groups. mice exhibited decrease levels cytokines IL-17 when compared group. result this provided an insight that can be potential for psoriasis.